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dc.contributor.authorGüner, I.
dc.contributor.authorUzun, D. D.
dc.contributor.authorYaman, M. O.
dc.contributor.authorGenç, H.
dc.contributor.authorGelişgen, R.
dc.contributor.authorKorkmaz, G. G.
dc.contributor.authorŞimşek, G.
dc.date.accessioned2021-12-12T16:56:46Z
dc.date.available2021-12-12T16:56:46Z
dc.date.issued2013
dc.identifier.issn0163-4984
dc.identifier.urihttps://doi.org/10.1007/s12011-013-9722-8
dc.identifier.urihttps://hdl.handle.net/20.500.11857/2731
dc.description.abstractIntermittent hypoxia is the most common pattern of hypoxic exposure in humans. The effect of chronic long-term intermittent hypobaric hypoxia (CLTIHH) on bone metabolism is not investigated. We examined the effect of CLTIHH on bone metabolism and the role of nitric oxide (NO) in this process. The rats were divided into three groups in this study. The animals in groups I and II have been exposed to CLTIHH. The animals in group II were also treated with nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester. To obtain CLTIHH, rats were placed in a hypobaric chamber (430 mm Hg; 5 h/day, 5 days/week, 5 weeks). The group III (control) rats breathed room air in the same environment. At the begining of the experiments, bone mineral density (BMD) of the animals were measured, and blood samples were collected from the tail vein. After the 5-week CLTIHH period, the same measurements were repeated. Parathyroid hormone, calcium, phosphate, bone alkaline phosphatase (b-ALP), NO, interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha levels were determined. The cytokines, NO levels, and BMD in CLTIHH-induced rats were higher compared with baseline and control values. The cytokines, b-ALP, and BMD increased while NO levels decreased in the group II compared with baseline values. BMD values of group II were lower than group I but higher than control group. Our results suggested that CLTIHH has positive effects on bone density. Intermittent hypoxia protocols may be developed for treatment and prevention of osteopenia and osteoporosis. © 2013 Springer Science+Business Media New York.en_US
dc.language.isoengen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.identifier.doi10.1007/s12011-013-9722-8
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone metabolismen_US
dc.subjectBone mineral densityen_US
dc.subjectCytokinesen_US
dc.subjectIntermittent hypoxiaen_US
dc.subjectl-NAMEen_US
dc.subjectNitric oxideen_US
dc.titleThe effect of chronic long-term intermittent hypobaric hypoxia on bone mineral density in rats: Role of nitric oxideen_US
dc.typearticle
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Biyokimya Anabilim Dalı
dc.identifier.volume154en_US
dc.identifier.startpage262en_US
dc.identifier.issue2en_US
dc.identifier.endpage267en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid6602284082
dc.authorscopusid55760700100
dc.authorscopusid54410003100
dc.authorscopusid24450294400
dc.authorscopusid35552319500
dc.authorscopusid55366092800
dc.authorscopusid55760700700
dc.identifier.scopus2-s2.0-84880284566en_US
dc.identifier.pmidPubMed: 23771686en_US


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