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dc.contributor.authorAsav, Engin
dc.contributor.authorSağıroğlu, Ayten
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.date.accessioned2021-12-12T17:00:45Z
dc.date.available2021-12-12T17:00:45Z
dc.date.issued2016
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.urihttps://doi.org/10.1002/elan.201500324
dc.identifier.urihttps://hdl.handle.net/20.500.11857/2885
dc.description.abstractCalretinin (CAL) is calcium binding protein, and its levels in blood and cerebrospinal fluids are increased, since its expression is increased various cancer types. A novel biosensor system fabricated by immobilization of a specific antibody to CAL, anti-Calretinin (anti-CAL), onto a gold electrode surface via an effective covalent binding method using mercaptohexanol, epichlorohydrin, and ethanolamine was reported for the sensitive, selective, and accurate analysis of CAL. The proposed biosensor showed a linear calibration range between 1 ng/mL and 5 ng/mL. LOD and LOQ values were determined as 0.11 ng/mL and 0.38 ng/mL, respectively. The standard deviation related to the reproducibility of the new biosensor system was calculated as 3.95%. Lastly, in order to state the applicability of the biosensor to early diagnosis of CAL in practice, artificial serum samples spiked with CAL have been analyzed by the proposed biosensor.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z 678]en_US
dc.description.sponsorshipThis work was funded by TUBITAK (The Scientific and Technological Research Council of Turkey, Project numbers: 113Z 678).en_US
dc.language.isoengen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofElectroanalysisen_US
dc.identifier.doi10.1002/elan.201500324
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalretininen_US
dc.subjectepichlorohydrinen_US
dc.subjectcancer biomarkeren_US
dc.subjectimmunosensoren_US
dc.subjectElectrochemical Impedance Spectroscopyen_US
dc.titleQuantitative Analysis of a Promising Cancer Biomarker, Calretinin, by a Biosensing System Based on Simple and Effective Immobilization Processen_US
dc.typearticle
dc.authoridAsav, Engin/0000-0002-6232-3388
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.identifier.volume28en_US
dc.identifier.startpage334en_US
dc.identifier.issue2en_US
dc.identifier.endpage342en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid25935968900
dc.authorscopusid6603077608
dc.authorscopusid6506764918
dc.identifier.wosWOS:000370138000011en_US
dc.identifier.scopus2-s2.0-84963657222en_US
dc.authorwosidAsav, Engin/AAG-4182-2021
dc.authorwosidAsav, Engin/AAG-1170-2021
dc.authorwosidSezginturk, Mustafa Kemal/AAY-1439-2021


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